Protein–protein interactions of PDE4 family members — Functions, interactions and therapeutic value
نویسندگان
چکیده
منابع مشابه
Protein-protein interactions of PDE4 family members - Functions, interactions and therapeutic value.
The second messenger cyclic adenosine monophosphate (cAMP) is ubiquitous and directs a plethora of functions in all cells. Although theoretically freely diffusible through the cell from the site of its synthesis it is not evenly distributed. It rather is shaped into gradients and these gradients are established by phospodiesterases (PDEs), the only enzymes that hydrolyse cAMP and thereby termin...
متن کاملInteractions of a hemidesmosome component and actinin family members.
Hemidesmosomes are multimeric protein complexes that attach epithelial cells to their underlying matrix and serve as cell surface anchorage sites for the keratin cytoskeleton. Two hemidesmosome components, the alpha6beta4 integrin heterodimer and a human autoantigen termed BP180, are transmembrane proteins that link the extracellular matrix to the keratin network in cells. Here, we report that ...
متن کاملalpha?synuclein structure, functions, and interactions
at present, when a clinical diagnosis of parkinson’s disease (pd) is made, serious damage has already been done to nerve cells of the substantia nigra pars compacta. the diagnosis of pd in its earlier stages, before this irreversible damage, would be of enormous benefit for future treatment strategies designed to slow or halt the progression of this disease that possibly prevents accumulation o...
متن کاملSocial and Religious Functions Performed by the Ritual Speech Act of “ya Allah” in Iranian Interactions
The current study was carried out to investigate the functions of the ritual speech act of ‘ya Allah’ (literally meaning ‘O God’) employed by Iranians in social interactions. To this end, sixty-two Persian native speakers of different age groups, ranging from 35 to 85, of both genders were observed in 250 natural situations such as daily interactions, gatherings, public or private places and lo...
متن کاملTabletops and Therapeutic Interactions
Writing in 1957 Carl Rogers, a pioneer of person-centred therapy, identified an empowering client-therapist relationship as the essence of a therapeutic process and proposed that an empowering relationship could, in and of itself, create the necessary and sufficient conditions for successful outcomes in mental health settings [17]. Whilst modern psychological theories no longer favour an exclus...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cellular Signalling
سال: 2016
ISSN: 0898-6568
DOI: 10.1016/j.cellsig.2015.10.005